Z-LEHD-FMK
- Product Name
- Z-LEHD-FMK
- CAS No.
- 210345-04-3
- Chemical Name
- Z-LEHD-FMK
- Synonyms
- CS-1506;abs813893;Z-LEHD-FMK;CASPASE-9 INHIBITOR;Z-LE(OME)HD(OME)-FMK;CASPASE-9 INHIBITOR I;Z-LEHD-FLUOROMETHYLKETONE;Z-LEU-GLU(OME)-HIS-ASP(OME)-FMK;Z-LE(OME)HD(OME)-FLUOROMETHYLKETONE;Z-LEU-GLU-HIS-ASP-FLUOROMETHYLKETONE
- CBNumber
- CB3758272
- Molecular Formula
- C32H43FN6O10
- Formula Weight
- 690.73
- MOL File
- Mol file
Z-LEHD-FMK Property
- Boiling point:
- 1008.2±65.0 °C(Predicted)
- Density
- 1.272±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO.
- form
- powder
- pka
- 11.11±0.46(Predicted)
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- J64966
- Product name
- Z-Leu-Glu(OMe)-His-Asp(OMe)-fluoromethyl ketone trifluoroacetate salt hydrate
- Packaging
- 1mg
- Price
- $242
- Updated
- 2023/06/20
- Product number
- B3233
- Product name
- Z-LEHD-FMK
- Packaging
- 1mg
- Price
- $259
- Updated
- 2021/12/16
- Product number
- B3233
- Product name
- Z-LEHD-FMK
- Packaging
- 5mg
- Price
- $715
- Updated
- 2021/12/16
- Product number
- INB0000771
- Product name
- Z-LEHD-FMK
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $811.34
- Updated
- 2021/12/16
- Product number
- orb573379
- Product name
- Z-LEHD-FMK
- Purity
- >98%
- Packaging
- 100mg
- Price
- $2245.7
- Updated
- 2021/12/16
Z-LEHD-FMK Chemical Properties,Usage,Production
Uses
A cell-permeable inhibitor of caspase-9, which exhibits competitive and irreversible inhibition
Biological Activity
Cell-permeable inhibitor of caspase-9. Inhibits MG 132-induced cancer cell death and protects isolated rat hearts against ischemia-reperfusion injury. Neuroprotective following cerebral ischemia in rats in vivo .
References
[1]. ozoren n, kim k, burns tf, et al. the caspase 9 inhibitor z-lehd-fmk protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. cancer res, 2000, 60(22): 6259-6265.
[2]. mouw g, zechel jl, zhou y, et al. caspase-9 inhibition after focal cerebral ischemia improves outcome following reversible focal ischemia. metab brain dis, 2002, 17(3): 143-151.
[3]. colak a, karaoğlan a, barut s, et al. neuroprotection and functional recovery after application of the caspase-9 inhibitor z-lehd-fmk in a rat model of traumatic spinal cord injury. j neurosurg spine, 2005, 2(3): 327-334.
Z-LEHD-FMK Preparation Products And Raw materials
Raw materials
Preparation Products
Z-LEHD-FMK Suppliers
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- United States
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